human SETX shRNA silencing Adenovirus

Name 
Ad-h-SETX-shRNA
Cat No 
shADV-222745
Availability
7-8 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human SETX.

shADV-222745
Ad-h-SETX-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human SETX (senataxin). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Validated
No
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
ALS4; amyotrophic lateral sclerosis 4 protein; AOA2; bA479K20.2; probable helicase senataxin; SCAR1; Sen1; SEN1 homolog; Senataxin
Description (eCommerce)
Mutations in Senataxin result in the neurodegenerative disorders Ataxia-Oculomotor Apraxia 2 (AOA2) and amyotrophic lateral sclerosis (ALS4). Senataxin bears an RNA/DNA helicase domain suggesting a role in DNA and RNA processing and has recently been found to be involved in the DNA damage response.
Description (Vector)
SETX encodes a protein named for its homology to the Sen1p protein of fungi which has RNA helicase activity encoded by a domain at the C-terminal end of the protein. The protein encoded by this gene contains a DNA/RNA helicase domain at its C-terminal end which suggests that it may be involved in both DNA and RNA processing. Mutations in this gene have been associated with ataxia-ocular apraxia-2 (AOA2) and an autosomal dominant form of juvenile amyotrophic lateral sclerosis (ALS4).
Gene ID
23064
Gene Name (eCommerce)
senataxin
Gene Name (Vector)
senataxin
Gene Symbol
SETX
HGNC ID
HGNC:445
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
8034
ORF Size (bp)
8034 bp
Protein Name (eCommerce)
Probable helicase senataxin
RefSeq ID
NM_015046
RefSeq Synonyms
NM_015046, BC137350, BC032600,
Research Areas
Amyotrophic Lateral Sclerosis (ALS),Apoptosis,DNA Damage/Repair,Helicase Activity,Neurobiology,Neurodegeneration,RNA Processing,Ubiquitination
Research Areas (Faceted)
neurobiology,cell_biology,genetics,transcription_translation
Species
human
Target Sentence
Mutations in Senataxin result in the neurodegenerative disorders Ataxia-Oculomotor Apraxia 2 (AOA2) and amyotrophic lateral sclerosis (ALS4). Senataxin bears an RNA/DNA helicase domain suggesting a role in DNA and RNA processing and has recently been found to be involved in the DNA damage response.
UniGene ID
Hs.460317
UniProt ID (eCommerce)
Q7Z333

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.