human SERPINI1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human SERPINI1.
shADV-222714
Ad-h-SERPINI1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human SERPINI1 (serpin family I member 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
neuroserpin; PI12
Description (Vector)
SERPINI1 encodes a member of the serpin superfamily of serine proteinase inhibitors. The protein is primarily secreted by axons in the brain, and preferentially reacts with and inhibits tissue-type plasminogen activator. It is thought to play a role in the regulation of axonal growth and the development of synaptic plasticity. Mutations in this gene result in familial encephalopathy with neuroserpin inclusion bodies (FENIB), which is a dominantly inherited form of familial encephalopathy and epilepsy characterized by the accumulation of mutant neuroserpin polymers. Multiple alternatively spliced variants, encoding the same protein, have been identified.
Gene ID
5274
Gene Name (Vector)
serpin family I member 1
Gene Symbol
SERPINI1
HGNC ID
HGNC:8943
ORF Size (aa)
1233
ORF Size (bp)
1233 bp
RefSeq ID
NM_005025
RefSeq Synonyms
NM_005025, NM_001122752, BC018043,
Species
human
UniGene ID
Hs.478153
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.