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human SERPINE1 shRNA silencing Adenovirus

Name 
Ad-h-SERPINE1-shRNA
Cat No 
shADV-222704
Availability
Immediate
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human SERPINE1.

shADV-222704
Ad-h-SERPINE1-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human SERPINE1 (serpin family E member 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
PAI; PAI-1; PAI1; PLANH1
Description (Vector)
SERPINE1 encodes a member of the serine proteinase inhibitor (serpin) superfamily. This member is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are associated with thrombophilia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Gene ID
5054
Gene Name (Vector)
serpin family E member 1
Gene Symbol
SERPINE1
HGNC ID
HGNC:8583
ORF Size (aa)
1209
ORF Size (bp)
1209 bp
RefSeq ID
NM_000602
RefSeq Synonyms
NM_001165413, NM_000602, BC010860,
Species
human
UniGene ID
Hs.713079

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.