human SERF1A shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human SERF1A.
shADV-222636
Ad-h-SERF1A-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human SERF1A (small EDRK-rich factor 1A). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
4F5; FAM2A; H4F5; SERF1; SMAM1
Description (Vector)
SERF1A is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. The duplication region includes both a telomeric and a centromeric copy of this gene. Deletions of this gene, the telomeric copy, often accompany deletions of the neighboring SMN1 gene in spinal muscular atrophy (SMA) patients, and so it is thought that this gene may be a modifier of the SMA phenotype. The function of this protein is not known; however, it bears low-level homology with the RNA-binding domain of matrin-cyclophilin, a protein which colocalizes with small nuclear ribonucleoproteins (snRNPs) and the SMN1 gene product. Alternatively spliced transcripts have been documented but it is unclear whether alternative splicing occurs for both the centromeric and telomeric copies of the gene.
Gene ID
8293
Gene Name (Vector)
small EDRK-rich factor 1A
Gene Symbol
SERF1A
HGNC ID
HGNC:10755
ORF Size (aa)
189
RefSeq ID
NM_021967
RefSeq Synonyms
NM_022968, NM_021967, BC093882, BC093880, BC035932, BC021174,
Species
human
UniGene ID
Hs.559428
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.