human SEC63 shRNA silencing Adenovirus

Name 
Ad-h-SEC63-shRNA
Cat No 
shADV-222508
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human SEC63.

shADV-222508
Ad-h-SEC63-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human SEC63 (SEC63 homolog, protein translocation regulator). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
DNAJC23; ERdj2; PCLD2; PRO2507; SEC63 protein translocation regulator; SEC63L; SEC63-like protein; translocation protein SEC63 homolog
Description (eCommerce)
The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. Translocation protein SEC63 homolog, encoded by the gene SEC63, and the SEC62 protein are found to be associated with ribosome-free SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway [taken from NCBI Entrez Gene (Gene ID: 11231)].
Description (Vector)
The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The protein encoded by this gene and SEC62 protein are found to be associated with ribosome-free SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. The encoded protein is an integral membrane protein located in the rough ER.
Gene ID
11231
Gene Name (eCommerce)
SEC63 homolog, protein translocation regulator
Gene Name (Vector)
SEC63 homolog, protein translocation regulator
Gene Symbol
SEC63
HGNC ID
HGNC:21082
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2283
ORF Size (bp)
2283 bp
Protein Name (eCommerce)
Translocation protein SEC63 homolog
RefSeq ID
NM_007214
RefSeq Synonyms
NM_007214, BC048287, BC047221,
Research Areas
Protein Folding
Research Areas (Faceted)
cell_biology
Species
human
Target Sentence
The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. Translocation protein SEC63 homolog, encoded by the gene SEC63, and the SEC62 protein are found to be associated with ribosome-free SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway [taken from NCBI Entrez Gene (Gene ID: 11231)].
UniGene ID
Hs.26904
UniProt ID (eCommerce)
Q9UGP8

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.