human SAV1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human SAV1.
shADV-222278
Ad-h-SAV1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human SAV1 (salvador family WW domain containing protein 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
SAV; WW45; WWP4
Description (Vector)
WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein with two WW domains, a SARAH domain, and a coiled-coil region and is ubiquitously expressed in adult tissues. This protein binds to MST1 (mammalian sterile 20-like kinase 1) and promotes MST1-induced apoptosis. It has also been shown to bind to HAX1 (hematopoietic cell-specific protein 1 (HS1)-associated protein X-1) and to attenuate the anti-apoptotic effects of HAX1. Studies in human and mouse suggest this gene acts as a tumor suppressor.
Gene ID
60485
Gene Name (Vector)
salvador family WW domain containing protein 1
Gene Symbol
SAV1
HGNC ID
HGNC:17795
ORF Size (aa)
1152
RefSeq ID
NM_021818
RefSeq Synonyms
NM_021818, BC020537,
Species
human
UniGene ID
Hs.642842
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.