human SARDH shRNA silencing Adenovirus

Name 
Ad-h-SARDH-shRNA
Cat No 
shADV-222252
Availability
7-8 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human SARDH.

shADV-222252
Ad-h-SARDH-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human SARDH (sarcosine dehydrogenase). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Validated
No
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
BPR-2; dimethylglycine dehydrogenase-like 1; DMGDHL1; SAR; sarcosine dehydrogenase, mitochondrial; SARD; SarDH; SDH
Description (eCommerce)
SARDH is an enzyme localized to the mitochondrial matrix which catalyzes the oxidative demethylation of sarcosine. This enzyme is distinct from another mitochondrial matrix enzyme, dimethylglycine dehydrogenase, which catalyzes a reaction resulting in the formation of sarcosine. Mutations in this gene are associated with sarcosinemia. Alternatively spliced transcript variants have been described. [taken from NCBI Entrez Gene (Gene ID: 1757)].
Description (Vector)
SARDH encodes an enzyme localized to the mitochondrial matrix which catalyzes the oxidative demethylation of sarcosine. This enzyme is distinct from another mitochondrial matrix enzyme, dimethylglycine dehydrogenase, which catalyzes a reaction resulting in the formation of sarcosine. Mutations in this gene are associated with sarcosinemia. Alternatively spliced transcript variants have been described.
Gene ID
1757
Gene Name (eCommerce)
sarcosine dehydrogenase
Gene Name (Vector)
sarcosine dehydrogenase
Gene Symbol
SARDH
HGNC ID
HGNC:10536
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2757
ORF Size (bp)
2757 bp
Protein Name (eCommerce)
Sarcosine dehydrogenase, mitochondrial
RefSeq ID
NM_007101
RefSeq Synonyms
NM_007101, NM_001134707, BC144035, BC136364, BC136363,
Research Areas
Mitochondrion
Research Areas (Faceted)
cell_biology
Species
human
Target Sentence
SARDH is an enzyme localized to the mitochondrial matrix which catalyzes the oxidative demethylation of sarcosine. This enzyme is distinct from another mitochondrial matrix enzyme, dimethylglycine dehydrogenase, which catalyzes a reaction resulting in the formation of sarcosine. Mutations in this gene are associated with sarcosinemia. Alternatively spliced transcript variants have been described. [taken from NCBI Entrez Gene (Gene ID: 1757)].
UniGene ID
Hs.198003
UniProt ID (eCommerce)
Q9UL12

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.