human RUNX2 shRNA silencing Adenovirus

Name
Ad-h-RUNX2-shRNA

Cat No
shADV-222117

Availability
Immediate

This is an Adenovirus expressing shRNA for silencing of Human RUNX2.

shADV-222117

Ad-h-RUNX2-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human RUNX2 (runt-related transcription factor 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

shRNA Validated

Yes

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

acute myeloid leukemia 3 protein;AML3;CBFA1;CBF-alpha-1;CCD;CCD1;CLCD;Core-binding factor subunit alpha-1;core-binding factor, runt domain, alpha subunit 1;oncogene AML-3;OSF2;OSF-2;osteoblast-specific transcription factor 2;PEA2aA;PEA2-alpha A;PEBP2aA;PEBP2-alpha A;polyomavirus enhancer-binding protein 2 alpha A subunit;runt-related transcription factor 2;SL3/AKV core-binding factor alpha A subunit;SL3-3 enhancer factor 1 alpha A subunit

Description (eCommerce)

RUNX2 is a member of the RUNX family of transcription factors and encodes a nuclear protein with a Runt DNA-binding domain. RUNX2 is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. RUNX2 can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. [provided by RefSeq, Jul 2016] [taken from NCBI Entrez Gene (Gene ID: 860)].

Description (Vector)

RUNX2 is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Mutations in this gene have been associated with the bone development disorder cleidocranial dysplasia (CCD). Transcript variants that encode different protein isoforms result from the use of alternate promoters as well as alternate splicing.

Gene ID

860

Gene Name (eCommerce)

runt related transcription factor 2

Gene Name (Vector)

runt-related transcription factor 2

Gene Symbol

RUNX2

HGNC ID

HGNC:10472

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

1524

ORF Size (bp)

1524 bp

Protein Name (eCommerce)

Runt-related transcription factor 2

RefSeq ID

NM_004348

RefSeq Synonyms

NM_004348, NM_001278478, NM_001024630, NM_001015051, BC160022,

Research Areas (Faceted)

cancer,signal_transduction,cell_biology,immunology,stem_cell_biology,transcription_translation

Species

human

UniGene ID

Hs.535845

UniProt ID (eCommerce)

Q13950

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.