human RTN4 shRNA silencing Adenovirus

Name 
Ad-h-RTN4-shRNA
Cat No 
shADV-222092
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human RTN4.

shADV-222092
Ad-h-RTN4-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human RTN4 (reticulon 4). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
ASY; Nbla00271; Nbla10545; NI220/250; NOGO; NOGO-A; Nogo-B; Nogo-C; NOGOC; NSP; NSP-CL; RTN-X; RTN4-A; RTN4-B1; RTN4-B2; RTN4-C
Description (Vector)
RTN4 belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. The product of this gene is a potent neurite outgrowth inhibitor which may also help block the regeneration of the central nervous system in higher vertebrates. Alternatively spliced transcript variants derived both from differential splicing and differential promoter usage and encoding different isoforms have been identified.
Gene ID
57142
Gene Name (Vector)
reticulon 4
Gene Symbol
RTN4
HGNC ID
HGNC:14085
ORF Size (aa)
597
RefSeq ID
NM_007008
RefSeq Synonyms
NM_207521, NM_207520, NM_153828, NM_020532, NM_007008, NM_001321904, NM_001321863, NM_001321862, NM_001321861, NM_001321860, NM_001321859, BC152555, BC152425, BC150182, BC139928, BC016165,
Species
human
UniGene ID
Hs.704007

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.