human RPS19 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human RPS19.
shADV-221853
Ad-h-RPS19-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human RPS19 (ribosomal protein S19). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
40S ribosomal protein S19; DBA; DBA1; eS19; S19; small ribosomal subunit protein eS19
Description (eCommerce)
Ribosomal protein S19 (RPS19) is a ribosomal protein that is a component of the 40S subunit. RPS19 belongs to the S19E family of ribosomal proteins. It is located in the cytoplasm. Mutations in this gene cause Diamond-Blackfan anemia (DBA), a constitutional erythroblastopenia characterized by absent or decreased erythroid precursors, in a subset of patients. This suggests a possible extra-ribosomal function for this gene in erythropoietic differentiation and proliferation, in addition to its ribosomal function [taken from NCBI Entrez Gene (Gene ID: 6223)].
Description (Vector)
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S19E family of ribosomal proteins. It is located in the cytoplasm. Mutations in this gene cause Diamond-Blackfan anemia (DBA), a constitutional erythroblastopenia characterized by absent or decreased erythroid precursors, in a subset of patients. This suggests a possible extra-ribosomal function for this gene in erythropoietic differentiation and proliferation, in addition to its ribosomal function. Higher expression levels of this gene in some primary colon carcinomas compared to matched normal colon tissues has been observed. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.
Gene ID
6223
Gene Name (eCommerce)
ribosomal protein S19
Gene Name (Vector)
ribosomal protein S19
Gene Symbol
RPS19
HGNC ID
HGNC:10402
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
438
Protein Name (eCommerce)
40S ribosomal protein S19
RefSeq ID
NM_001022
RefSeq Synonyms
NM_001321485, NM_001321484, NM_001321483, NM_001022, BC018616, BC007615, BC000023,
Research Areas
Gene Expression,Host-Virus Interactions,Metabolism/Metabolic Process,mRNA Binding,RNA Binding,RNA Processing,Translational Control
Research Areas (Faceted)
cell_biology,genetics,infectious_disease,metabolism,transcription_translation
Species
human
Target Sentence
Ribosomal protein S19 (RPS19) is a ribosomal protein that is a component of the 40S subunit. RPS19 belongs to the S19E family of ribosomal proteins. It is located in the cytoplasm. Mutations in this gene cause Diamond-Blackfan anemia (DBA), a constitutional erythroblastopenia characterized by absent or decreased erythroid precursors, in a subset of patients. This suggests a possible extra-ribosomal function for this gene in erythropoietic differentiation and proliferation, in addition to its ribosomal function [taken from NCBI Entrez Gene (Gene ID: 6223)].
UniGene ID
Hs.438429
UniProt ID (eCommerce)
P39019
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.