human RPL10A shRNA silencing Adenovirus

Name 
Ad-h-RPL10A-shRNA
Cat No 
shADV-221562
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human RPL10A.

shADV-221562
Ad-h-RPL10A-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human RPL10A (ribosomal protein L10a). Available with optional GFP reporter or cell-specific promoter.

Request a Quote

Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
60S ribosomal protein L10a; CSA19; Csa-19; L10A; large ribosomal subunit protein uL1; NEDD6; NEDD-6; neural precursor cell expressed developmentally down-regulated protein 6
Description (eCommerce)
The gene RPL10A encodes 60S ribosomal protein L10a, that, as its name implies, is a component of the 60S subunit. The protein belongs to the L1P family of ribosomal proteins and is located in the cytoplasm. Studies in mice have shown that the expression of the ribosomal protein L10a gene is downregulated in neural precursor cells during development. This gene previously was referred to as NEDD6 (neural precursor cell expressed, developmentally downregulated 6) [taken from NCBI Entrez Gene (Gene ID: 4736)].
Description (Vector)
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L1P family of ribosomal proteins. It is located in the cytoplasm. The expression of this gene is downregulated in the thymus by cyclosporin-A (CsA), an immunosuppressive drug. Studies in mice have shown that the expression of the ribosomal protein L10a gene is downregulated in neural precursor cells during development. This gene previously was referred to as NEDD6 (neural precursor cell expressed, developmentally downregulated 6), but it has been renamed RPL10A (ribosomal protein 10a). As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.
Gene ID
4736
Gene Name (eCommerce)
ribosomal protein L10a
Gene Name (Vector)
ribosomal protein L10a
Gene Symbol
RPL10A
HGNC ID
HGNC:10299
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
654
Protein Name (eCommerce)
60S ribosomal protein L10a
RefSeq ID
NM_007104
RefSeq Synonyms
NM_007104, BC070216, BC011366, BC006791,
Research Areas
Gene Expression,Host-Virus Interactions,Metabolism/Metabolic Process,Mitochondrion,RNA Binding,RNA Processing,Translational Control
Research Areas (Faceted)
genetics,transcription_translation,infectious_disease,metabolism,cell_biology
Species
human
Target Sentence
The gene RPL10A encodes 60S ribosomal protein L10a, that, as its name implies, is a component of the 60S subunit. The protein belongs to the L1P family of ribosomal proteins and is located in the cytoplasm. Studies in mice have shown that the expression of the ribosomal protein L10a gene is downregulated in neural precursor cells during development. This gene previously was referred to as NEDD6 (neural precursor cell expressed, developmentally downregulated 6) [taken from NCBI Entrez Gene (Gene ID: 4736)].
UniGene ID
Hs.546269
UniProt ID (eCommerce)
P62906

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.