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human ROR2 shRNA silencing Adenovirus

Name 
Ad-h-ROR2-shRNA
Cat No 
shADV-221490
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human ROR2.

shADV-221490
Ad-h-ROR2-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human ROR2 (receptor tyrosine kinase like orphan receptor 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
BDB; BDB1; neurotrophic tyrosine kinase receptor-related 2; Neurotrophic tyrosine kinase, receptor-related 2; NTRKR2; tyrosine-protein kinase transmembrane receptor ROR2
Description (eCommerce)
Receptor tyrosine kinase-like orphan receptor 2 (ROR2) is a receptor protein tyrosine kinase and type I transmembrane protein that belongs to the ROR subfamily of cell surface receptors. ROR2 may be involved in the early formation of the chondrocytes and may be required for cartilage and growth plate development [taken from NCBI Entrez Gene (Gene ID: 4920)].
Description (Vector)
ROR2 is a receptor protein tyrosine kinase and type I transmembrane protein that belongs to the ROR subfamily of cell surface receptors. The protein may be involved in the early formation of the chondrocytes and may be required for cartilage and growth plate development. Mutations in this gene can cause brachydactyly type B, a skeletal disorder characterized by hypoplasia/aplasia of distal phalanges and nails. In addition, mutations in this gene can cause the autosomal recessive form of Robinow syndrome, which is characterized by skeletal dysplasia with generalized limb bone shortening, segmental defects of the spine, brachydactyly, and a dysmorphic facial appearance.
Gene ID
4920
Gene Name (eCommerce)
receptor tyrosine kinase like orphan receptor 2
Gene Name (Vector)
receptor tyrosine kinase like orphan receptor 2
Gene Symbol
ROR2
HGNC ID
HGNC:10257
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2832
ORF Size (bp)
2832 bp
Protein Name (eCommerce)
Tyrosine-protein kinase transmembrane receptor ROR2
RefSeq ID
NM_004560
RefSeq Synonyms
NM_004560, NM_001318204, BC130522,
Research Areas
Cardiac Development,Cardiology,Cardiovascular,Immunology,Kinase/Phosphatase,Signal Transduction,Wnt Signaling
Research Areas (Faceted)
signal_transduction,cardiovascular,immunology,cell_biology,signal_transduction,developmental_biology
Species
human
Target Sentence
Receptor tyrosine kinase-like orphan receptor 2 (ROR2) is a receptor protein tyrosine kinase and type I transmembrane protein that belongs to the ROR subfamily of cell surface receptors. ROR2 may be involved in the early formation of the chondrocytes and may be required for cartilage and growth plate development [taken from NCBI Entrez Gene (Gene ID: 4920)].
UniGene ID
Hs.644776
UniProt ID (eCommerce)
Q01974

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.