human RNF20 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human RNF20.
shADV-221398
Ad-h-RNF20-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human RNF20 (ring finger protein 20). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
BRE1; BRE1 E3 ubiquitin ligase homolog; BRE1A; BRE1-A; E3 ubiquitin-protein ligase BRE1A; hBRE1; homolog of S. cerevisiae BRE1; RING finger protein 20; RING-type E3 ubiquitin transferase BRE1A
Description (eCommerce)
The conjugation of ubiquitin to proteins is an important means to regulate protein activity for many cellular processes. Targeting of proteins by ubiquitination occurs in three main steps that involve the activation of ubiquitin by E1 enzymes, the carrying of ubiquitin to the target protein by E2 enzymes, and the ligation of ubiquitin to the target protein by E3 enzymes. Ring finger protein 20 (RNF20) is a member of the RING type E3 ubiquitin ligases. RNF20 forms a complex with RNF40 to carry out H2B monoubiquitination in association with hPAF and the UbcH6 ubiquitin E2-conjugating enzyme. H2B monoubiquitination by RNF40/RNF20 has been shown to be associated with increased H3 methylation and gene transcription.
Description (Vector)
RNF20 shares similarity with BRE1 of S. cerevisiae. The protein encoded by this human gene is an E3 ubiquitin ligase that regulates chromosome structure by monoubiquitinating histone H2B. This protein acts as a putative tumor suppressor and positively regulates the p53 tumor suppressor as well as numerous histone H2A and H2B genes. In contrast, this protein also suppresses the expression of several protooncogenes and growth-related genes, including many genes that are induced by epidermal growth factor. This gene selectively suppresses the expression of some genes by interfering with chromatin recruitment of transcription elongation factor SII (TFIIS).
Gene ID
56254
Gene Name (eCommerce)
ring finger protein 20
Gene Name (Vector)
ring finger protein 20
Gene Symbol
RNF20
HGNC ID
HGNC:10062
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2928
ORF Size (bp)
2928 bp
Protein Name (eCommerce)
E3 ubiquitin-protein ligase BRE1A
RefSeq ID
NM_019592
RefSeq Synonyms
NM_019592, BC152309, BC110585, BC110584,
Research Areas
Chromatin Remodeling,Histone Modification,Ubiquitination,Zinc-finger
Research Areas (Faceted)
cell_biology,genetics
Species
human
Target Sentence
The conjugation of ubiquitin to proteins is an important means to regulate protein activity for many cellular processes. Targeting of proteins by ubiquitination occurs in three main steps that involve the activation of ubiquitin by E1 enzymes, the carrying of ubiquitin to the target protein by E2 enzymes, and the ligation of ubiquitin to the target protein by E3 enzymes. Ring finger protein 20 (RNF20) is a member of the RING type E3 ubiquitin ligases. RNF20 forms a complex with RNF40 to carry out H2B monoubiquitination in association with hPAF and the UbcH6 ubiquitin E2-conjugating enzyme. H2B monoubiquitination by RNF40/RNF20 has been shown to be associated with increased H3 methylation and gene transcription.
UniGene ID
Hs.656088
UniProt ID (eCommerce)
Q5VTR2
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.