human RGR shRNA silencing Adenovirus

Name
Ad-h-RGR-shRNA

Cat No
shADV-221105

Availability
7-8 weeks

This is an Adenovirus expressing shRNA for silencing of Human RGR.

shADV-221105

Ad-h-RGR-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human RGR (retinal G protein coupled receptor). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Validated

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

RP44

Description (Vector)

RGR encodes a putative retinal G-protein coupled receptor. The gene is a member of the opsin subfamily of the 7 transmembrane, G-protein coupled receptor 1 family. Like other opsins which bind retinaldehyde, it contains a conserved lysine residue in the seventh transmembrane domain. The protein acts as a photoisomerase to catalyze the conversion of all-trans-retinal to 11-cis-retinal. The reverse isomerization occurs with rhodopsin in retinal photoreceptor cells. The protein is exclusively expressed in tissue adjacent to retinal photoreceptor cells, the retinal pigment epithelium and Mueller cells. RGR may be associated with autosomal recessive and autosomal dominant retinitis pigmentosa (arRP and adRP, respectively). Alternative splicing results in multiple transcript variants encoding different isoforms.

Gene ID

5995

Gene Name (Vector)

retinal G protein coupled receptor

Gene Symbol

RGR

HGNC ID

HGNC:9990

ORF Size (aa)

888

RefSeq ID

NM_002921

RefSeq Synonyms

NM_002921, NM_001012722, NM_001012720, BC011349,

Species

human

UniGene ID

Hs.1544

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.