human RFC2 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human RFC2.
shADV-221037
Ad-h-RFC2-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human RFC2 (replication factor C subunit 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
A1 40 kDa subunit; Activator 1 40 kDa subunit; activator 1 subunit 2; replication factor C (activator 1) 2, 40kDa; Replication factor C 40 kDa subunit; replication factor C subunit 2; RF-C 40 kDa subunit; RFC40
Description (eCommerce)
The Replication factor C (RFC) heteropentamer includes RFC1, RFC2, RFC3, RFC4, and RFC5. The RFC heteropentamer is part of the multiprotein DNA replicase that functions to replicate DNA prior to cell division and repair DNA damage. RFC is the clamp loader ATPase associated with the DNA replicase. As the clamp loader, RFC uses ATP to recruit, open, and close the PCNA ring to link it to DNA for replication and repair. RFC2 is the 40 kDa subunit of RFC that is part of the core complex formed with RFC4 and RFC5.
Description (Vector)
The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins, proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also called activator 1, is a protein complex consisting of five distinct subunits of 145, 40, 38, 37, and 36.5 kD. This gene encodes the 40 kD subunit, which has been shown to be responsible for binding ATP. Deletion of this gene has been associated with Williams syndrome. Alternatively spliced transcript variants encoding distinct isoforms have been described.
Gene ID
5982
Gene Name (eCommerce)
replication factor C subunit 2
Gene Name (Vector)
replication factor C subunit 2
Gene Symbol
RFC2
HGNC ID
HGNC:9970
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
963
Protein Name (eCommerce)
Replication factor C subunit 2
RefSeq ID
NM_181471
RefSeq Synonyms
NM_181471, NM_002914, NM_001278793, NM_001278792, NM_001278791, BC002813,
Research Areas
Cell Cycle,DNA Damage/Repair,DNA Replication,Fanconi anemia,Homologous Recombination,Neurobiology,Replication,Signal Transduction,Telomeric Maintenance
Research Areas (Faceted)
signal_transduction,cell_biology,cell_cycle,genetics,transcription_translation,neurobiology,cell_biology,cell_cycle,genetics
Species
human
Target Sentence
The Replication factor C (RFC) heteropentamer includes RFC1, RFC2, RFC3, RFC4, and RFC5. The RFC heteropentamer is part of the multiprotein DNA replicase that functions to replicate DNA prior to cell division and repair DNA damage. RFC is the clamp loader ATPase associated with the DNA replicase. As the clamp loader, RFC uses ATP to recruit, open, and close the PCNA ring to link it to DNA for replication and repair. RFC2 is the 40 kDa subunit of RFC that is part of the core complex formed with RFC4 and RFC5.
UniGene ID
Hs.647062
UniProt ID (eCommerce)
P35250
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.