human RAPGEF1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human RAPGEF1.
shADV-220730
Ad-h-RAPGEF1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human RAPGEF1 (Rap guanine nucleotide exchange factor 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
C3G; CRK SH3-binding GNRP; GRF2; Guanine nucleotide-releasing factor 2; guanine nucleotide-releasing factor 2 (specific for crk proto-oncogene); Protein C3G; Rap guanine nucleotide exchange factor (GEF) 1; rap guanine nucleotide exchange factor 1
Description (eCommerce)
CRK SH3-binding GNRP (C3G) is a guanine nucleotide exchange factor (GEF) that binds to the SH3 domain of CRK and GRB2/ASH and catalyzes the exchange of GDP for GTP on GTPases of the Ras family. C3G has been reported to be involved in signaling that mediates cell adhesion and migration.
Description (Vector)
RAPGEF1 encodes a human guanine nucleotide exchange factor. It transduces signals from CRK by binding the SH3 domain of CRK, and activating several members of the Ras family of GTPases. This signaling cascade that may be involved in apoptosis, integrin-mediated signal transduction, and cell transformation. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some variants has not been determined.
Gene ID
2889
Gene Name (eCommerce)
Rap guanine nucleotide exchange factor 1
Gene Name (Vector)
Rap guanine nucleotide exchange factor 1
Gene Symbol
RAPGEF1
HGNC ID
HGNC:4568
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3288
ORF Size (bp)
3288 bp
Protein Name (eCommerce)
Rap guanine nucleotide exchange factor 1
RefSeq ID
NM_005312
RefSeq Synonyms
NM_198679, NM_005312, NM_001304275, BC041710,
Research Areas
B-cell Receptor Signaling,Cancer,Cytokine Signaling,EPO Signaling,GPCR Signaling,HGF Signaling,IFN Signaling,Immunology,Insulin Signaling,Interleukin Signaling,Kidney Cancer,Neurobiology,Neurodevelopment,Neurogenesis,NGF Signaling,PDGF Signaling,Prostate Cancer,Signal Transduction,T-cell Receptor Signaling
Research Areas (Faceted)
cancer,developmental_biology,immunology,neurobiology,signal_transduction
Species
human
Target Sentence
CRK SH3-binding GNRP (C3G) is a guanine nucleotide exchange factor (GEF) that binds to the SH3 domain of CRK and GRB2/ASH and catalyzes the exchange of GDP for GTP on GTPases of the Ras family. C3G has been reported to be involved in signaling that mediates cell adhesion and migration.
UniGene ID
Hs.127897
UniProt ID (eCommerce)
Q13905
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.