human RANBP1 shRNA silencing Adenovirus

Name 
Ad-h-RANBP1-shRNA
Cat No 
shADV-220700
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human RANBP1.

shADV-220700
Ad-h-RANBP1-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human RANBP1 (RAN binding protein 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
HpaII tiny fragments locus 9A; HTF9A; Ran-binding protein 1; RanBP1; ran-specific GTPase-activating protein; testis secretory sperm-binding protein Li 221n
Description (eCommerce)
Ran-binding protein 1 (RanBP1) binds to the GTP-binding protein, Ran, when it is specifically complexed with GTP. RanBP1 binding to GTP-charged RAN increases the catalytic efficiency of GTP hydrolysis activated by RanGAP, the Ran specific GTPase-activating protein. RanBP1 is also a negative regulator of RCC1 which functions in the nuclear pore transport process and cell cycle progression.
Description (Vector)
Ran/TC4-binding protein, RanBP1, interacts specifically with GTP-charged RAN. RANBP1 encodes a 23-kD protein that binds to RAN complexed with GTP but not GDP. RANBP1 does not activate GTPase activity of RAN but does markedly increase GTP hydrolysis by the RanGTPase-activating protein (RanGAP1). The RANBP1 cDNA encodes a 201-amino acid protein that is 92% similar to its mouse homolog. In both mammalian cells and in yeast, RANBP1 acts as a negative regulator of RCC1 by inhibiting RCC1-stimulated guanine nucleotide release from RAN.
Gene ID
5902
Gene Name (eCommerce)
RAN binding protein 1
Gene Name (Vector)
RAN binding protein 1
Gene Symbol
RANBP1
HGNC ID
HGNC:9847
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
603
Protein Name (eCommerce)
Ran-specific GTPase-activating protein
RefSeq ID
NM_002882
RefSeq Synonyms
NM_002882, NM_001278641, NM_001278640, NM_001278639, BC152785,
Research Areas
Cancer,Cell Cycle,Host-Virus Interactions,Nuclear Import/Export,Signal Transduction,Transport,Viral Carcinogenesis
Research Areas (Faceted)
cancer,cell_biology,cell_cycle,genetics,infectious_disease,signal_transduction
Species
human
Target Sentence
Ran-binding protein 1 (RanBP1) binds to the GTP-binding protein, Ran, when it is specifically complexed with GTP. RanBP1 binding to GTP-charged RAN increases the catalytic efficiency of GTP hydrolysis activated by RanGAP, the Ran specific GTPase-activating protein. RanBP1 is also a negative regulator of RCC1 which functions in the nuclear pore transport process and cell cycle progression.
UniGene ID
Hs.24763
UniProt ID (eCommerce)
P43487

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.