human PTPN21 shRNA silencing Adenovirus

Name 
Ad-h-PTPN21-shRNA
Cat No 
shADV-220319
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human PTPN21.

shADV-220319
Ad-h-PTPN21-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human PTPN21 (protein tyrosine phosphatase, non-receptor type 21). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
70
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
PTPD1; PTPRL10
Description (Vector)
PTPN21 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal domain, similar to cytoskeletal- associated proteins including band 4.1, ezrin, merlin, and radixin. This PTP was shown to specially interact with BMX/ETK, a member of Tec tyrosine kinase family characterized by a multimodular structures including PH, SH3, and SH2 domains. The interaction of this PTP with BMX kinase was found to increase the activation of STAT3, but not STAT2 kinase. Studies of the similar gene in mice suggested the possible roles of this PTP in liver regeneration and spermatogenesis.
Gene ID
11099
Gene Name (Vector)
protein tyrosine phosphatase, non-receptor type 21
Gene Symbol
PTPN21
HGNC ID
HGNC:9651
ORF Size (aa)
3525
ORF Size (bp)
3525 bp
RefSeq ID
NM_007039
RefSeq Synonyms
NM_007039, BC167856,
Species
human
UniGene ID
Hs.437040

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.