human PTPN1 shRNA silencing Adenovirus

Name
Ad-h-PTPN1-shRNA

Cat No
shADV-220307

Availability
4-5 weeks

This is an Adenovirus expressing shRNA for silencing of Human PTPN1.

shADV-220307

Ad-h-PTPN1-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human PTPN1 (protein tyrosine phosphatase, non-receptor type 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

shRNA Validated

Yes

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

protein tyrosine phosphatase, placental; protein-tyrosine phosphatase 1B; PTP1B; PTP-1B; tyrosine-protein phosphatase non-receptor type 1

Description (eCommerce)

Protein-tyrosine phosphatases 1B (PTP1B) is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTP1B has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation.

Description (Vector)

PTPN1 is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation.

Gene ID

5770

Gene Name (eCommerce)

protein tyrosine phosphatase, non-receptor type 1

Gene Name (Vector)

protein tyrosine phosphatase, non-receptor type 1

Gene Symbol

PTPN1

HGNC ID

HGNC:9642

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

1308

ORF Size (bp)

1308 bp

Protein Name (eCommerce)

Tyrosine-protein phosphatase non-receptor type 1

RefSeq ID

NM_002827

RefSeq Synonyms

NM_002827, NM_001278618, BC018164, BC015660,

Research Areas

Cancer,Cytokine Signaling,Cytoskeleton,EGFR Signaling,HGF Signaling,IFN Signaling,Immunology,Insulin Signaling,JAK-STAT Signaling,Kinase/Phosphatase,Leptin Signaling,PDGF Signaling,Phosphatase,Prolactin Signaling,Signal Transduction,Translational Control

Research Areas (Faceted)

cancer,cell_biology,immunology,signal_transduction,transcription_translation

Species

human

Target Sentence

UniGene ID

Hs.417549

UniProt ID (eCommerce)

P18031

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.