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human PTGS2 shRNA silencing Adenovirus

Name 
Ad-h-PTGS2-shRNA
Cat No 
shADV-220257
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human PTGS2.

shADV-220257
Ad-h-PTGS2-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human PTGS2 (prostaglandin-endoperoxide synthase 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
COX2; COX-2; cyclooxygenase 2; cyclooxygenase 2b; Cyclooxygenase-2; GRIPGHS; hCox-2; PGG/HS; PGH synthase 2; PGHS-2; PHS II; PHS-2; prostaglandin G/H synthase 2; prostaglandin H2 synthase 2; Prostaglandin-endoperoxide synthase 2; prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
Description (eCommerce)
COX-2 (cyclooxygenase-2) is also known as Prostaglandin-endoperoxide synthase (PTGS) and is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase [taken from NCBI Entrez Gene (Gene ID: 5134)].
Description (Vector)
Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes the inducible isozyme. It is regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis.
Gene ID
5743
Gene Name (eCommerce)
prostaglandin-endoperoxide synthase 2
Gene Name (Vector)
prostaglandin-endoperoxide synthase 2
Gene Symbol
PTGS2
HGNC ID
HGNC:9605
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1815
ORF Size (bp)
1815 bp
Protein Name (eCommerce)
Prostaglandin G/H synthase 2
RefSeq ID
NM_000963
RefSeq Synonyms
NM_000963, BC013734,
Research Areas
Alzheimer's Disease,Apoptosis,Cancer,Cardiovascular,Cell Cycle,FGF Signaling,Hypoxia,Immunology,Lung Cancer,Metabolism/Metabolic Process,MicroRNAs in Cancer,Neurobiology,Neurodegeneration,Neurodevelopment,NF-kB Signaling,Signal Transduction,T-cell Receptor Signaling,TNF Signaling,VEGF Signaling
Research Areas (Faceted)
cardiovascular,cancer,genetics,signal_transduction,neurobiology,cell_biology,cell_cycle,signal_transduction,developmental_biology,cell_biology,metabolism,immunology,metabolism,neurobiology,developmental_biology,signal_transduction,immunology
Species
human
Target Sentence
COX-2 (cyclooxygenase-2) is also known as Prostaglandin-endoperoxide synthase (PTGS) and is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase [taken from NCBI Entrez Gene (Gene ID: 5134)].
UniGene ID
Hs.196384
UniProt ID (eCommerce)
P35354

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.