human PRKCZ shRNA silencing Adenovirus

Name
Ad-h-PRKCZ-shRNA

Cat No
shADV-219869

Availability
Immediate

This is an Adenovirus expressing shRNA for silencing of Human PRKCZ.

shADV-219869

Ad-h-PRKCZ-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human PRKCZ (protein kinase C zeta). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

shRNA Validated

Yes

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

PKC-ZETA; PKC2

Description (Vector)

Protein kinase C (PKC) zeta is a member of the PKC family of serine/threonine kinases which are involved in a variety of cellular processes such as proliferation, differentiation and secretion. Unlike the classical PKC isoenzymes which are calcium-dependent, PKC zeta exhibits a kinase activity which is independent of calcium and diacylglycerol but not of phosphatidylserine. Furthermore, it is insensitive to typical PKC inhibitors and cannot be activated by phorbol ester. Unlike the classical PKC isoenzymes, it has only a single zinc finger module. These structural and biochemical properties indicate that the zeta subspecies is related to, but distinct from other isoenzymes of PKC. Alternative splicing results in multiple transcript variants encoding different isoforms.

Gene ID

5590

Gene Name (Vector)

protein kinase C zeta

Gene Symbol

PRKCZ

HGNC ID

HGNC:9412

ORF Size (aa)

1779

ORF Size (bp)

1779 bp

RefSeq ID

NM_002744

RefSeq Synonyms

NM_002744, NM_001242874, NM_001033582, NM_001033581, BC014270, BC008058,

Species

human

UniGene ID

Hs.496255

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.