human PRKAR2B shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human PRKAR2B.
shADV-219856
Ad-h-PRKAR2B-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human PRKAR2B (protein kinase cAMP-dependent type II regulatory subunit beta). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
PRKAR2; RII-BETA
Description (Vector)
cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. This subunit has been shown to interact with and suppress the transcriptional activity of the cAMP responsive element binding protein 1 (CREB1) in activated T cells. Knockout studies in mice suggest that this subunit may play an important role in regulating energy balance and adiposity. The studies also suggest that this subunit may mediate the gene induction and cataleptic behavior induced by haloperidol.
Gene ID
5577
Gene Name (Vector)
protein kinase cAMP-dependent type II regulatory subunit beta
Gene Symbol
PRKAR2B
HGNC ID
HGNC:9392
ORF Size (aa)
1257
ORF Size (bp)
1257 bp
RefSeq ID
NM_002736
RefSeq Synonyms
NM_002736, BC075800,
Species
human
UniGene ID
Hs.433068
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.