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human PRDX5 shRNA silencing Adenovirus

Name 
Ad-h-PRDX5-shRNA
Cat No 
shADV-219783
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human PRDX5.

shADV-219783
Ad-h-PRDX5-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human PRDX5 (peroxiredoxin 5). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
ACR1; Alu corepressor 1; Alu co-repressor 1; antioxidant enzyme B166; AOEB166; B166; epididymis secretory protein Li 55; HEL-S-55; liver tissue 2D-page spot 71B; peroxiredoxin V; peroxiredoxin-5, mitochondrial; peroxisomal antioxidant enzyme; PLP; PMP20; PRDX6; PRXV; prx-V; SBBI10; thioredoxin peroxidase PMP20; thioredoxin reductase; TPx type VI
Description (eCommerce)
Peroxiredoxin V reduces hydrogen peroxide and alkyl hydroperoxides with reducing equivalents provided through the thioredoxin system. It is involved in intracellular redox signaling [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P30044].
Description (Vector)
PRDX5 encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein may play an antioxidant protective role in different tissues under normal conditions and during inflammatory processes. This protein interacts with peroxisome receptor 1. The crystal structure of this protein in its reduced form has been resolved to 1.5 angstrom resolution. PRDX5 uses alternate in-frame translation initiation sites to generate mitochondrial or peroxisomal/cytoplasmic forms. Three transcript variants encoding distinct isoforms have been identified for this gene.
Gene ID
25824
Gene Name (eCommerce)
peroxiredoxin 5
Gene Name (Vector)
peroxiredoxin 5
Gene Symbol
PRDX5
HGNC ID
HGNC:9355
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
378
Protein Name (eCommerce)
Peroxiredoxin-5, mitochondrial
RefSeq ID
NM_012094
RefSeq Synonyms
NM_181652, NM_181651, NM_012094, BC171733, BC143849, BC113725, BC113723, BC110983,
Research Areas
Apoptosis,Immunology,Mitochondrion,RNA Binding,RNA Processing
Research Areas (Faceted)
cell_biology,genetics,immunology,transcription_translation
Species
human
Target Sentence
Peroxiredoxin V reduces hydrogen peroxide and alkyl hydroperoxides with reducing equivalents provided through the thioredoxin system. It is involved in intracellular redox signaling [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P30044].
UniGene ID
Hs.502823
UniProt ID (eCommerce)
P30044

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.