human PRDM16 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human PRDM16.
shADV-219761
Ad-h-PRDM16-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human PRDM16 (PR/SET domain 16). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CMD1LL; KMT8F; LVNC8; MEL1; PFM13
Description (Vector)
The reciprocal translocation t(1;3)(p36;q21) occurs in a subset of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). This gene is located near the 1p36.3 breakpoint and has been shown to be specifically expressed in the t(1:3)(p36,q21)-positive MDS/AML. The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal PR domain. The translocation results in the overexpression of a truncated version of this protein that lacks the PR domain, which may play an important role in the pathogenesis of MDS and AML. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
Gene ID
63976
Gene Name (Vector)
PR/SET domain 16
Gene Symbol
PRDM16
HGNC ID
HGNC:14000
ORF Size (aa)
3771
ORF Size (bp)
3771 bp
RefSeq ID
NM_022114
RefSeq Synonyms
NM_199454, NM_022114, BC168363, BC161614,
Species
human
UniGene ID
Hs.99500
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.