human PRDM1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human PRDM1.
shADV-219746
Ad-h-PRDM1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human PRDM1 (PR/SET domain 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
Beta-interferon gene positive regulatory domain I-binding factor; beta-interferon gene positive-regulatory domain I binding factor; BLIMP1; BLIMP-1; B-lymphocyte-induced maturation protein 1; Positive regulatory domain I-binding factor 1; PR domain 1; PR domain containing 1, with ZNF domain; PR domain zinc finger protein 1; PR domain-containing protein 1; PRDI-BF1; PRDI-binding factor 1; PRDI-binding factor-1
Description (eCommerce)
PDRM1, aka Blimp-1, is a transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. PDRM1 binds specifically to the PRDI (positive regulatory domain I element) of the beta-IFN gene promoter and acts as a repressor of beta-interferon gene expression. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/O75626].
Description (Vector)
PRDM1 encodes a protein that acts as a repressor of beta-interferon gene expression. The protein binds specifically to the PRDI (positive regulatory domain I element) of the beta-IFN gene promoter. Transcription of this gene increases upon virus induction. Two alternatively spliced transcript variants that encode different isoforms have been reported.
Gene ID
639
Gene Name (eCommerce)
PR/SET domain 1
Gene Name (Vector)
PR/SET domain 1
Gene Symbol
PRDM1
HGNC ID
HGNC:9346
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2076
ORF Size (bp)
2076 bp
Protein Name (eCommerce)
PR domain zinc finger protein 1
RefSeq ID
NM_001198
RefSeq Synonyms
NM_182907, NM_001198, BC103835, BC103834, BC103833, BC103832,
Research Areas
Gene Expression,Immunology,Interleukin Signaling,Methyltransferase,Signal Transduction,Transcription Factor/Regulator,Zinc-finger
Research Areas (Faceted)
cell_biology,immunology,signal_transduction,transcription_translation
Species
human
Target Sentence
PDRM1, aka Blimp-1, is a transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. PDRM1 binds specifically to the PRDI (positive regulatory domain I element) of the beta-IFN gene promoter and acts as a repressor of beta-interferon gene expression. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/O75626].
UniGene ID
Hs.436023
UniProt ID (eCommerce)
O75626
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.