human PRCC shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human PRCC.
shADV-219741
Ad-h-PRCC-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human PRCC (papillary renal cell carcinoma (translocation-associated)). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
papillary renal cell carcinoma (translocation-associated); papillary renal cell carcinoma translocation-associated gene protein; PRCC, proline rich mitotic checkpoint control factor; proline-rich protein PRCC; RCCP1; TPRC
Description (eCommerce)
In a subset of papillary renal cell carcinomas, a t(X;1)(p11;q21) chromosome translocation has been repeatedly reported and is thought to be the cause of the cancer. As a result of the translocation, the transcription factor TFE3 on the X chromosome becomes fused to the PRCC (papillary renal cell carcinoma translocation-associated) gene on chromosome 1. The fused gene results in the fusion of N-terminal proline-rich region of the protein encoded by this gene to the entire TFE3 protein. This protein has been shown to interact with the mitotic checkpoint protein MAD2B, which suggests that the dominant-negative effect of the fusion protein with TFE3 may lead to a mitotic checkpoint defect [taken from NCBI GeneID:5546].
Description (Vector)
PRCC encodes a protein that may play a role in pre-mRNA splicing. Chromosomal translocations (X;1)(p11;q21) that result in fusion of this gene to TFE3 (GeneID 7030) have been associated with papillary renal cell carcinoma. A PRCC-TFE3 fusion protein is expressed in affected carcinomas and is likely associated with altered gene transactivation. This fusion protein has also been associated with disruption of the cell cycle.
Gene ID
5546
Gene Name (eCommerce)
proline rich mitotic checkpoint control factor
Gene Name (Vector)
papillary renal cell carcinoma (translocation-associated)
Gene Symbol
PRCC
HGNC ID
HGNC:9343
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1476
ORF Size (bp)
1476 bp
Protein Name (eCommerce)
Proline-rich protein PRCC
RefSeq ID
NM_005973
RefSeq Synonyms
NM_005973, BC010450, BC004913,
Research Areas
Cancer,Cell Cycle,Transcriptional Misregulation in Cancer
Research Areas (Faceted)
cancer,cell_biology,cell_cycle,genetics,transcription_translation
Species
human
Target Sentence
In a subset of papillary renal cell carcinomas, a t(X;1)(p11;q21) chromosome translocation has been repeatedly reported and is thought to be the cause of the cancer. As a result of the translocation, the transcription factor TFE3 on the X chromosome becomes fused to the PRCC (papillary renal cell carcinoma translocation-associated) gene on chromosome 1. The fused gene results in the fusion of N-terminal proline-rich region of the protein encoded by this gene to the entire TFE3 protein. This protein has been shown to interact with the mitotic checkpoint protein MAD2B, which suggests that the dominant-negative effect of the fusion protein with TFE3 may lead to a mitotic checkpoint defect [taken from NCBI GeneID:5546].
UniGene ID
Hs.516948
UniProt ID (eCommerce)
Q92733
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.