human PNPLA1 shRNA silencing Adenovirus

Name 
Ad-h-PNPLA1-shRNA
Cat No 
shADV-219311
Availability
7-8 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human PNPLA1.

shADV-219311
Ad-h-PNPLA1-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human PNPLA1 (patatin like phospholipase domain containing 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Validated
No
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
ARCI10; dJ50J22.1
Description (Vector)
PNPLA1 belongs to the patatin-like phospholipase (PNPLA) family, which is characterized by the presence of a highly conserved patatin domain. PNPLA family members have diverse lipolytic and acyltransferase activities, and are key elements in lipid metabolism. While other members of this family have been well characterized, the function of this gene remained an enigma. However, recent studies show that this gene is expressed in the skin epidermal keratinocytes, and has a role in glycerophospholipid metabolism in the cutaneous barrier. Consistent with these observations, mutations in this gene are associated with ichthyosis in human (autosomal recessive congenital ichthyoses, ARCI) and dog. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Gene ID
285848
Gene Name (Vector)
patatin like phospholipase domain containing 1
Gene Symbol
PNPLA1
HGNC ID
HGNC:21246
ORF Size (aa)
1341
ORF Size (bp)
1341 bp
RefSeq ID
NM_173676
RefSeq Synonyms
NM_173676, NM_001145717, NM_001145716, BC103907, BC103906, BC103905,
Species
human
UniGene ID
Hs.407002

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.