human PNN shRNA silencing Adenovirus

Name 
Ad-h-PNN-shRNA
Cat No 
shADV-219307
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human PNN.

shADV-219307
Ad-h-PNN-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human PNN (pinin, desmosome associated protein). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
140 kDa nuclear and cell adhesion-related phosphoprotein; desmosome-associated protein; domain-rich serine protein; DRS; DRS protein; DRSP; melanoma metastasis clone A protein; memA; neutrophil protein; nuclear protein SDK3; pinin; SDK3; SR-like protein
Description (eCommerce)
PNN is a nuclear and cell adhesion-related protein involved in cell adhesion, mRNA processing, and transcriptional regulation. PNN functions as a transcriptional regulator by relieving CtBP1-mediated repression of the E-cadherin gene. In the role of mRNA processing, PNN functions as a splicing regulator. The role of PNN in transcription and mRNA processing suggests the role of PNN as a coupling factor for the two processes.
Gene ID
5411
Gene Name (eCommerce)
pinin, desmosome associated protein
Gene Name (Vector)
pinin, desmosome associated protein
Gene Symbol
PNN
HGNC ID
HGNC:9162
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2154
ORF Size (bp)
2154 bp
Protein Name (eCommerce)
Pinin
RefSeq ID
NM_002687
RefSeq Synonyms
NM_002687, BC062602,
Research Areas
Cancer,Cell Cycle,Gene Expression,mRNA Processing,mRNA Splicing,RNA Processing,RNA Transport,Spliceosome,Transcription Factor/Regulator,Tumor Suppressors/Oncoproteins
Research Areas (Faceted)
cancer,cell_biology,cell_cycle,genetics,transcription_translation,cell_biology,genetics,cancer
Species
human
Target Sentence
PNN is a nuclear and cell adhesion-related protein involved in cell adhesion, mRNA processing, and transcriptional regulation. PNN functions as a transcriptional regulator by relieving CtBP1-mediated repression of the E-cadherin gene. In the role of mRNA processing, PNN functions as a splicing regulator. The role of PNN in transcription and mRNA processing suggests the role of PNN as a coupling factor for the two processes.
UniGene ID
Hs.409965
UniProt ID (eCommerce)
Q9H307

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.