human PMVK shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human PMVK.
shADV-219282
Ad-h-PMVK-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human PMVK (phosphomevalonate kinase). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
hPMK; HUMPMKI; phosphomevalonate kinase; PMK; PMKA; PMKASE; POROK1; testis tissue sperm-binding protein Li 95mP
Description (eCommerce)
PMVK is a peroxisomal enzyme that is a member of the galactokinase, homoserine kinase, mevalonate kinase, and phosphomevalonate kinase (GHMP) family of ATP-dependent enzymes. PMVK protein catalyzes the conversion of mevalonate 5-phosphate to mevalonate 5-diphosphate, which is the fifth step in the mevalonate pathway of isoprenoid biosynthesis [taken from NCBI Entrez Gene (Gene ID: 10654)].
Description (Vector)
PMVK encodes a peroxisomal enzyme that catalyzes the conversion of mevalonate 5-phosphate into mevalonate 5-diphosphate, the fifth reaction of the cholesterol biosynthetic pathway. Studies in rat show that the message level and the enzyme activity of this protein is regulated by sterol, and that this regulation is coordinated with 3-hydroxy-3-methylglutaryl coenzyme A reductase, the rate-limiting enzyme of cholesterol biosynthesis.
Gene ID
10654
Gene Name (eCommerce)
phosphomevalonate kinase
Gene Name (Vector)
phosphomevalonate kinase
Gene Symbol
PMVK
HGNC ID
HGNC:9141
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
579
Protein Name (eCommerce)
Phosphomevalonate kinase
RefSeq ID
NM_006556
RefSeq Synonyms
NM_006556, NM_001323012, NM_001323011, BC007694, BC006089,
Research Areas
Metabolism/Metabolic Process
Research Areas (Faceted)
cell_biology,metabolism
Species
human
Target Sentence
PMVK is a peroxisomal enzyme that is a member of the galactokinase, homoserine kinase, mevalonate kinase, and phosphomevalonate kinase (GHMP) family of ATP-dependent enzymes. PMVK protein catalyzes the conversion of mevalonate 5-phosphate to mevalonate 5-diphosphate, which is the fifth step in the mevalonate pathway of isoprenoid biosynthesis [taken from NCBI Entrez Gene (Gene ID: 10654)].
UniGene ID
Hs.30954
UniProt ID (eCommerce)
Q15126
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.