human PMPCA shRNA silencing Adenovirus

Name
Ad-h-PMPCA-shRNA

Cat No
shADV-219276

Availability
4-5 weeks

This is an Adenovirus expressing shRNA for silencing of Human PMPCA.

shADV-219276

Ad-h-PMPCA-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human PMPCA (peptidase, mitochondrial processing alpha subunit). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

90

shRNA Validated

Yes

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

Alpha-MPP; cerebellar ataxia 1 (autosomal recessive); Cerebellar ataxia-1; CLA1; CPD3; inositol polyphosphate-5-phosphatase, 72 kD; INPP5E; mitochondrial matrix processing protease, alpha subunit; mitochondrial-processing peptidase subunit alpha; P-55; SCAR2

Description (eCommerce)

PMPCA is found in the mitochondrion, where it represents the alpha subunit of a proteolytic heterodimer. This heterodimer is responsible for cleaving the transit peptide from nuclear-encoded mitochondrial proteins [taken from NCBI Entrez Gene (Gene ID: 23203)].

Gene ID

23203

Gene Name (eCommerce)

peptidase, mitochondrial processing alpha subunit

Gene Name (Vector)

peptidase, mitochondrial processing alpha subunit

Gene Symbol

PMPCA

HGNC ID

HGNC:18667

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

1578

ORF Size (bp)

1578 bp

Protein Name (eCommerce)

Mitochondrial-processing peptidase subunit alpha

RefSeq ID

NM_015160

RefSeq Synonyms

NM_015160, NM_001282946, NM_001282944, BC136599, BC132724, BC111399,

Research Areas

Metabolism/Metabolic Process,Mitochondrion

Research Areas (Faceted)

cell_biology,metabolism

Species

human

Target Sentence

PMPCA is found in the mitochondrion, where it represents the alpha subunit of a proteolytic heterodimer. This heterodimer is responsible for cleaving the transit peptide from nuclear-encoded mitochondrial proteins [taken from NCBI Entrez Gene (Gene ID: 23203)].

UniGene ID

Hs.495471

UniProt ID (eCommerce)

Q10713

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.