human PML shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human PML.
shADV-219268
Ad-h-PML-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human PML (promyelocytic leukemia). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
MYL; PML/RARA fusion; PP8675; probable transcription factor PML; promyelocytic leukemia protein; promyelocytic leukemia, inducer of; protein PML; RING finger protein 71; RNF71; TRIM19; tripartite motif protein TRIM19; tripartite motif-containing protein 19
Description (eCommerce)
PML is a member of RBCC/TRIM family of proteins that possess a RING finger domain, B-box, and coiled-coil domain. PML is a multifunctional protein involved in activities such as tumor growth suppression, hematopoietic differentiation, gene transcription, apoptotic induction, and viral immunity. PML is often involved in chromosomal translocations with the retinoic acid receptor alpha gene. PML-retinoic acid receptor translocations are associated with acute promyelocytic leukemia.
Description (Vector)
PML is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified.
Gene ID
5371
Gene Name (eCommerce)
promyelocytic leukemia
Gene Name (Vector)
promyelocytic leukemia
Gene Symbol
PML
HGNC ID
HGNC:9113
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2346
ORF Size (bp)
2346 bp
Protein Name (eCommerce)
Protein PML
RefSeq ID
NM_002675
RefSeq Synonyms
NM_033250, NM_033249, NM_033247, NM_033246, NM_033244, NM_033240, NM_033239, NM_033238, NM_002675, BC020994, BC000080,
Research Areas
Aging,Angiogenesis,Apoptosis,Breast Cancer,Cancer,Cell Cycle,DNA Damage/Repair,Histone Modification,Host-Virus Interactions,Hypoxia,IFN Signaling,Immunology,Innate Immunity,Kinase/Phosphatase,Leukemia,mTOR Signaling,Response to Virus,Signal Transduction,Telomeric Maintenance,TGF-beta Signaling,TNF Signaling,Transcription Factor/Regulator,Transcriptional Misregulation in Cancer,Translational Control,Tumor Suppressors/Oncoproteins,Zinc-finger
Research Areas (Faceted)
cancer,cell_biology,cell_cycle,developmental_biology,genetics,immunology,infectious_disease,signal_transduction,transcription_translation
Species
human
Target Sentence
PML is a member of RBCC/TRIM family of proteins that possess a RING finger domain, B-box, and coiled-coil domain. PML is a multifunctional protein involved in activities such as tumor growth suppression, hematopoietic differentiation, gene transcription, apoptotic induction, and viral immunity. PML is often involved in chromosomal translocations with the retinoic acid receptor alpha gene. PML-retinoic acid receptor translocations are associated with acute promyelocytic leukemia.
UniGene ID
Hs.526464
UniProt ID (eCommerce)
P29590
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.