human PLOD2 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human PLOD2.
shADV-219219
Ad-h-PLOD2-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human PLOD2 (procollagen-lysine,2-oxoglutarate 5-dioxygenase 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
BRKS2; LH2; TLH
Description (Vector)
PLOD2 is a membrane-bound homodimeric enzyme that is localized to the cisternae of the rough endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VIB have deficiencies in lysyl hydroxylase activity. Mutations in the coding region of this gene are associated with Bruck syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms.
Gene ID
5352
Gene Name (Vector)
procollagen-lysine,2-oxoglutarate 5-dioxygenase 2
Gene Symbol
PLOD2
HGNC ID
HGNC:9082
ORF Size (aa)
2277
ORF Size (bp)
2277 bp
RefSeq ID
NM_000935
RefSeq Synonyms
NM_182943, NM_000935, BC037169,
Species
human
UniGene ID
Hs.477866
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.