human PKLR shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human PKLR.
shADV-219031
Ad-h-PKLR-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human PKLR (pyruvate kinase, liver and RBC). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
PK1; PKL; PKR; PKRL; RPK
Description (Vector)
PKLR is a pyruvate kinase that catalyzes the transphosphorylation of phohsphoenolpyruvate into pyruvate and ATP, which is the rate-limiting step of glycolysis. Defects in this enzyme, due to gene mutations or genetic variations, are the common cause of chronic hereditary nonspherocytic hemolytic anemia (CNSHA or HNSHA). Multiple transcript variants encoding different isoforms have been found for this gene.
Gene ID
5313
Gene Name (Vector)
pyruvate kinase, liver and RBC
Gene Symbol
PKLR
HGNC ID
HGNC:9020
ORF Size (aa)
1725
ORF Size (bp)
1725 bp
RefSeq ID
NM_000298
RefSeq Synonyms
NM_181871, NM_000298, BC025737,
Species
human
UniGene ID
Hs.95990
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.