human PITX2 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human PITX2.
shADV-219008
Ad-h-PITX2-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human PITX2 (paired like homeodomain 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
ARP1; Brx1; IDG2; IGDS; IGDS2; IHG2; IRID2; Otlx2; PTX2; RGS; RIEG; RIEG1; RS
Description (Vector)
PITX2 encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. The encoded protein acts as a transcription factor and regulates procollagen lysyl hydroxylase gene expression. This protein plays a role in the terminal differentiation of somatotroph and lactotroph cell phenotypes, is involved in the development of the eye, tooth and abdominal organs, and acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin. Mutations in this gene are associated with Axenfeld-Rieger syndrome, iridogoniodysgenesis syndrome, and sporadic cases of Peters anomaly. A similar protein in other vertebrates is involved in the determination of left-right asymmetry during development. Alternatively spliced transcript variants encoding distinct isoforms have been described.
Gene ID
5308
Gene Name (Vector)
paired like homeodomain 2
Gene Symbol
PITX2
HGNC ID
HGNC:9005
ORF Size (aa)
975
ORF Size (bp)
975 bp
RefSeq ID
NM_000325
RefSeq Synonyms
NM_153427, NM_153426, NM_001204399, NM_001204398, NM_001204397, NM_000325, BC106010, BC013998,
Species
human
UniGene ID
Hs.643588
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.