human PIAS3 shRNA silencing Adenovirus

Product Info

Knockdown

>80% knockdown of mRNA in cultured cells

Viral Details

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Promoter

U6

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Gene Details

Species

Human

Gene Symbol

PIAS3

Gene Name

protein inhibitor of activated STAT 3

Gene ID

10401

Gene Synonyms

ZMIZ5

ORF Size

1887 bp

RefSeq#

NM_006099

Gene Description

PIAS3 encodes a member of the PIAS (protein inhibitor of activated STAT (signal transducer and activator of transcription)) family of transcriptional modulators. The protein functions as a SUMO (small ubiquitin-like modifier)-E3 ligase which catalyzes the covalent attachment of a SUMO protein to specific target substrates. It directly binds to several transcription factors and either blocks or enhances their activity. Alternatively spliced transcript variants of this gene have been identified, but the full-length nature of some of these variants has not been determined.

UniGene ID

Hs.435761

HGNC ID

HGNC:16861