human PIAS2 shRNA silencing Adenovirus

Name
Ad-h-PIAS2-shRNA

Cat No
shADV-218887

Availability
4-5 weeks

This is an Adenovirus expressing shRNA for silencing of Human PIAS2.

shADV-218887

Ad-h-PIAS2-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human PIAS2 (protein inhibitor of activated STAT 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

shRNA Validated

Yes

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

ARIP3; DIP; MIZ; MIZ1; PIASX; PIASX-ALPHA; PIASX-BETA; SIZ2; ZMIZ4

Description (Vector)

PIAS2 encodes a member of the protein inhibitor of activated STAT (PIAS) family. PIAS proteins function as SUMO E3 ligases and play important roles in many cellular processes by mediating the sumoylation of target proteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Isoforms of the encoded protein enhance the sumoylation of specific target proteins including the p53 tumor suppressor protein, c-Jun, and the androgen receptor. A pseudogene of this gene is located on the short arm of chromosome 4. The symbol MIZ1 has also been associated with ZBTB17 which is a different gene located on chromosome 1.

Gene ID

9063

Gene Name (Vector)

protein inhibitor of activated STAT 2

Gene Symbol

PIAS2

HGNC ID

HGNC:17311

ORF Size (aa)

1524

ORF Size (bp)

1524 bp

RefSeq ID

NM_004671

RefSeq Synonyms

NM_173206, NM_004671, NM_001324060, NM_001324059, NM_001324058, NM_001324057, NM_001324055, NM_001324054, NM_001324053, NM_001324052, NM_001324051, NM_001324049, NM_001324048, NM_001324047, NM_001324046, BC111060, BC015190,

Species

human

UniGene ID

Hs.658013

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.