human PGP shRNA silencing Adenovirus

Name 
Ad-h-PGP-shRNA
Cat No 
shADV-218767
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human PGP.

shADV-218767
Ad-h-PGP-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human PGP (phosphoglycolate phosphatase). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
83
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
aspartate-based ubiquitous Mg(2+)-dependent phosphatase; AUM; G3PP; glycerol-3-phosphate phosphatase; PGP; PGPase; Phosphoglycolate phosphatase
Description (eCommerce)
Glycerol-3-phosphate phosphatase (PGP) hydrolyzes glycerol-3-phosphate into glycerol. It regulates the cellular levels of glycerol-3-phosphate a metabolic intermediate of glucose, lipid and energy metabolism. Has been shown to have a 2-phosphoglycolate phosphatase activity and a tyrosine-protein phosphatase activity. However, their physiological relevance is unclear (PubMed:26755581). In vitro, has also a phosphatase activity toward ADP, ATP, GDP and GTP (By similarity) [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/A6NDG6].
Gene ID
283871
Gene Name (eCommerce)
phosphoglycolate phosphatase
Gene Name (Vector)
phosphoglycolate phosphatase
Gene Symbol
PGP
HGNC ID
HGNC:8909
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
966
ORF Size (bp)
966 bp
Protein Name (eCommerce)
Glycerol-3-phosphate phosphatase
RefSeq ID
NM_001042371
RefSeq Synonyms
NM_001042371, BC157035, BC156305,
Research Areas
Kinase/Phosphatase,Metabolism/Metabolic Process,Phosphatase
Research Areas (Faceted)
cell_biology,metabolism,signal_transduction
Species
human
Target Sentence
Glycerol-3-phosphate phosphatase (PGP) hydrolyzes glycerol-3-phosphate into glycerol. It regulates the cellular levels of glycerol-3-phosphate a metabolic intermediate of glucose, lipid and energy metabolism. Has been shown to have a 2-phosphoglycolate phosphatase activity and a tyrosine-protein phosphatase activity. However, their physiological relevance is unclear (PubMed:26755581). In vitro, has also a phosphatase activity toward ADP, ATP, GDP and GTP (By similarity) [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/A6NDG6].
UniGene ID
Hs.442634
UniProt ID (eCommerce)
A6NDG6

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.