human PGD shRNA silencing Adenovirus

Name 
Ad-h-PGD-shRNA
Cat No 
shADV-218729
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human PGD.

shADV-218729
Ad-h-PGD-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human PGD (phosphogluconate dehydrogenase). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
6PGD; 6-phosphogluconate dehydrogenase, decarboxylating
Description (eCommerce)
6-phosphogluconate dehydrogenase (PGD) is the second dehydrogenase in the pentose phosphate shunt. Deficiency of this enzyme is generally asymptomatic, and the inheritance of this disorder is autosomal dominant. Hemolysis results from combined deficiency of 6-phosphogluconate dehydrogenase and 6-phosphogluconolactonase suggesting a synergism of the two enzymopathies[taken from NCBI Entrez Gene (Gene ID: 5226)].
Description (Vector)
6-phosphogluconate dehydrogenase is the second dehydrogenase in the pentose phosphate shunt. Deficiency of this enzyme is generally asymptomatic, and the inheritance of this disorder is autosomal dominant. Hemolysis results from combined deficiency of 6-phosphogluconate dehydrogenase and 6-phosphogluconolactonase suggesting a synergism of the two enzymopathies.
Gene ID
5226
Gene Name (eCommerce)
phosphogluconate dehydrogenase
Gene Name (Vector)
phosphogluconate dehydrogenase
Gene Symbol
PGD
HGNC ID
HGNC:8891
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1452
ORF Size (bp)
1452 bp
Protein Name (eCommerce)
6-phosphogluconate dehydrogenase, decarboxylating
RefSeq ID
NM_002631
RefSeq Synonyms
NM_002631, NM_001304452, NM_001304451, BC000368,
Research Areas
Metabolism/Metabolic Process
Research Areas (Faceted)
cell_biology,metabolism
Species
human
Target Sentence
6-phosphogluconate dehydrogenase (PGD) is the second dehydrogenase in the pentose phosphate shunt. Deficiency of this enzyme is generally asymptomatic, and the inheritance of this disorder is autosomal dominant. Hemolysis results from combined deficiency of 6-phosphogluconate dehydrogenase and 6-phosphogluconolactonase suggesting a synergism of the two enzymopathies[taken from NCBI Entrez Gene (Gene ID: 5226)].
UniGene ID
Hs.464071
UniProt ID (eCommerce)
P52209

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.