human PFAS shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human PFAS.
shADV-218655
Ad-h-PFAS-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human PFAS (phosphoribosylformylglycinamidine synthase). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
FGAM synthase; FGAMS; FGAR amidotransferase; FGARAT; FGAR-AT; formylglycinamide ribonucleotide amidotransferase; formylglycinamide ribotide amidotransferase; formylglycinamide ribotide synthetase; GATD8; phosphoribosylformylglycinamidine synthase; PURL
Description (eCommerce)
Purines are necessary for many cellular processes, including DNA replication, transcription, and energy metabolism. Ten enzymatic steps are required to synthesize inosine monophosphate (IMP) in the de novo pathway of purine biosynthesis. Phosphoribosylformylglycinamidine synthase (PFAS) catalyzes the fourth step of IMP biosynthesis [taken from NCBI Entrez Gene (Gene ID: 5198)].
Description (Vector)
Purines are necessary for many cellular processes, including DNA replication, transcription, and energy metabolism. Ten enzymatic steps are required to synthesize inosine monophosphate (IMP) in the de novo pathway of purine biosynthesis. The enzyme encoded by this gene catalyzes the fourth step of IMP biosynthesis.
Gene ID
5198
Gene Name (eCommerce)
phosphoribosylformylglycinamidine synthase
Gene Name (Vector)
phosphoribosylformylglycinamidine synthase
Gene Symbol
PFAS
HGNC ID
HGNC:8863
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
4017
ORF Size (bp)
4017 bp
Protein Name (eCommerce)
Phosphoribosylformylglycinamidine synthase
RefSeq ID
NM_012393
RefSeq Synonyms
NM_012393, BC167158, BC146768,
Research Areas
Metabolism/Metabolic Process
Research Areas (Faceted)
cell_biology,metabolism
Species
human
Target Sentence
Purines are necessary for many cellular processes, including DNA replication, transcription, and energy metabolism. Ten enzymatic steps are required to synthesize inosine monophosphate (IMP) in the de novo pathway of purine biosynthesis. Phosphoribosylformylglycinamidine synthase (PFAS) catalyzes the fourth step of IMP biosynthesis [taken from NCBI Entrez Gene (Gene ID: 5198)].
UniGene ID
Hs.573976
UniProt ID (eCommerce)
O15067
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.