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human PDLIM7 shRNA silencing Adenovirus

Name 
Ad-h-PDLIM7-shRNA
Cat No 
shADV-218548
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human PDLIM7.

shADV-218548
Ad-h-PDLIM7-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human PDLIM7 (PDZ and LIM domain 7). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
1110003B01Rik; LIM domain protein; LIM mineralization protein; Lim mineralization protein 3; LMP; LMP1; LMP3; PDZ and LIM domain 7 (enigma); PDZ and LIM domain protein 7; protein enigma
Description (eCommerce)
LMP-1 (LIM mineralization protein) is a PDZ-domain and LIM-domain containing protein shown to have osteoinductive activity. Before the discovery of LMP-1, a protein highly homologous to LMP-1 was identified as Enigma protein in Drosophila. Drosophila Enigma was first identified in a screen of Enigma loss-of-function mutations as a modifier of Notch signaling. In animal cells enigma was shown to bind to the insulin receptor and the tyrosine kinase receptor, ret.
Description (Vector)
PDLIM7 is representative of a family of proteins composed of conserved PDZ and LIM domains. LIM domains are proposed to function in protein-protein recognition in a variety of contexts including gene transcription and development and in cytoskeletal interaction. The LIM domains of this protein bind to protein kinases, whereas the PDZ domain binds to actin filaments. The gene product is involved in the assembly of an actin filament-associated complex essential for transmission of ret/ptc2 mitogenic signaling. The biological function is likely to be that of an adapter, with the PDZ domain localizing the LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues. Alternative splicing of this gene results in multiple transcript variants.
Gene ID
9260
Gene Name (eCommerce)
PDZ and LIM domain 7
Gene Name (Vector)
PDZ and LIM domain 7
Gene Symbol
PDLIM7
HGNC ID
HGNC:22958
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
864
Protein Name (eCommerce)
PDZ and LIM domain protein 7
RefSeq ID
NM_005451
RefSeq Synonyms
NM_213636, NM_203352, NM_005451, BC084575, BC067806, BC001093,
Research Areas
Cytoskeleton,Immunology,Signal Transduction,Transcription Factor/Regulator
Research Areas (Faceted)
cell_biology,immunology,signal_transduction,transcription_translation
Species
human
Target Sentence
LMP-1 (LIM mineralization protein) is a PDZ-domain and LIM-domain containing protein shown to have osteoinductive activity. Before the discovery of LMP-1, a protein highly homologous to LMP-1 was identified as Enigma protein in Drosophila. Drosophila Enigma was first identified in a screen of Enigma loss-of-function mutations as a modifier of Notch signaling. In animal cells enigma was shown to bind to the insulin receptor and the tyrosine kinase receptor, ret.
UniGene ID
Hs.533040
UniProt ID (eCommerce)
Q9NR12

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.