human PDGFRA shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human PDGFRA.
shADV-218508
Ad-h-PDGFRA-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human PDGFRA (platelet derived growth factor receptor alpha). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
Alpha platelet-derived growth factor receptor; alpha-type platelet-derived growth factor receptor; CD antigen CD140a; CD140 antigen-like family member A; CD140A; CD140a antigen; PDGFR2; PDGFR-2; PDGF-R-alpha; PDGFR-alpha; Platelet-derived growth factor alpha receptor; platelet-derived growth factor receptor 2; platelet-derived growth factor receptor alpha; platelet-derived growth factor receptor, alpha polypeptide
Description (eCommerce)
Platelet derived growth factor receptor alpha is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both PDGFR alpha and beta polypeptides. PDGFR alpha plays a role in organ development, wound healing, and tumor progression [taken from NCBI Entrez Gene (Gene ID: 5156)].
Description (Vector)
PDGFRA encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies suggest that this gene plays a role in organ development, wound healing, and tumor progression. Mutations in this gene have been associated with idiopathic hypereosinophilic syndrome, somatic and familial gastrointestinal stromal tumors, and a variety of other cancers.
Gene ID
5156
Gene Name (eCommerce)
platelet derived growth factor receptor alpha
Gene Name (Vector)
platelet derived growth factor receptor alpha
Gene Symbol
PDGFRA
HGNC ID
HGNC:8803
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2232
ORF Size (bp)
2232 bp
Protein Name (eCommerce)
Platelet-derived growth factor receptor alpha
RefSeq ID
NM_006206
RefSeq Synonyms
NM_006206, BC063414, BC015186,
Research Areas
Angiogenesis,B-cell Receptor Signaling,Cancer,Cardiac Development,Cardiology,Cardiovascular,Cytoskeleton,EGFR Signaling,EGFR Signaling in Cancer,EPO Signaling,Fc Receptor Signaling,FGF Signaling,Glioma,Host-Virus Interactions,Immunology,Innate Immunity,Interleukin Signaling,JAK-STAT Signaling,Kinase/Phosphatase,MAPK Signaling,Neurobiology,NGF Signaling,PDGF Signaling,PI3K/Akt Signaling,PI3K-AKT Signaling in Cancer,Prostate Cancer,RAC1 Signaling,SCF-KIT Signaling,Signal Transduction,VEGF Signaling
Research Areas (Faceted)
cancer,cardiovascular,cell_biology,developmental_biology,immunology,infectious_disease,neurobiology,signal_transduction,stem_cell_biology
Species
human
Target Sentence
Platelet derived growth factor receptor alpha is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both PDGFR alpha and beta polypeptides. PDGFR alpha plays a role in organ development, wound healing, and tumor progression [taken from NCBI Entrez Gene (Gene ID: 5156)].
UniGene ID
Hs.74615
UniProt ID (eCommerce)
P16234
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.