human PCDHA6 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human PCDHA6.
shADV-218338
Ad-h-PCDHA6-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human PCDHA6 (protocadherin alpha 6). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CNR2; CNRN2; CNRS2; CRNR2; PCDH-ALPHA6
Description (Vector)
PCDHA6 is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined.
Gene ID
56142
Gene Name (Vector)
protocadherin alpha 6
Gene Symbol
PCDHA6
HGNC ID
HGNC:8672
ORF Size (aa)
2853
ORF Size (bp)
2853 bp
RefSeq ID
NM_018909
RefSeq Synonyms
NM_031849, NM_031848, NM_018909, BC036674,
Species
human
UniGene ID
Hs.199343
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.