human PARP1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human PARP1.
shADV-218230
Ad-h-PARP1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human PARP1 (poly(ADP-ribose) polymerase 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase); ADP-ribosyltransferase diphtheria toxin-like 1; ADP-ribosyltransferase NAD(+); ADPRT; ADPRT 1; ADPRT1; ARTD1; NAD(+) ADP-ribosyltransferase 1; pADPRT-1; PARP; PARP-1; poly (ADP-ribose) polymerase family, member 1; poly ADP-ribose polymerase 1; poly(ADP-ribose) synthetase; poly(ADP-ribosyl)transferase; polyADP-ribose synthase 1; PPOL
Description (eCommerce)
PARP1 (Poly-ADP-ribose polymerase 1) is a member of PARP family of enzymes that transfer the ADP-D-ribosyl group of NAD(+) to an acceptor carboxyl group on proteins. PARP1 catalyzes the poly-ADP-ribosylation of histone and non-histone proteins in response to DNA damage. The over-activation of PARP-1 in response to DNA damage has been shown to promote cell and tissue injury. This observation has initiated research into the therapeutic potential of PARP1 inhibitors in the treatment of cancer, cardiovascular disease, and brain injury.
Description (Vector)
PARP1 encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes.
Gene ID
142
Gene Name (eCommerce)
poly(ADP-ribose) polymerase 1
Gene Name (Vector)
poly(ADP-ribose) polymerase 1
Gene Symbol
PARP1
HGNC ID
HGNC:270
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3045
ORF Size (bp)
3045 bp
Protein Name (eCommerce)
Poly [ADP-ribose] polymerase 1
RefSeq ID
NM_001618
RefSeq Synonyms
NM_001618, BC037545,
Research Areas
Apoptosis,CD95/FAS Signaling,DNA Damage/Repair,Gene Expression,Host-Virus Interactions,Metabolism/Metabolic Process,NF-kB Signaling,Signal Transduction,Telomeric Maintenance,TGF-beta Signaling,Transcription Factor/Regulator,Zinc-finger
Research Areas (Faceted)
cell_biology,genetics,transcription_translation,immunology,infectious_disease,metabolism,signal_transduction
Species
human
Target Sentence
PARP1 (Poly-ADP-ribose polymerase 1) is a member of PARP family of enzymes that transfer the ADP-D-ribosyl group of NAD(+) to an acceptor carboxyl group on proteins. PARP1 catalyzes the poly-ADP-ribosylation of histone and non-histone proteins in response to DNA damage. The over-activation of PARP-1 in response to DNA damage has been shown to promote cell and tissue injury. This observation has initiated research into the therapeutic potential of PARP1 inhibitors in the treatment of cancer, cardiovascular disease, and brain injury.
UniGene ID
Hs.177766
UniProt ID (eCommerce)
P09874
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.