human PARK7 shRNA silencing Adenovirus

DJ1; DJ-1; epididymis secretory sperm binding protein Li 67p; GATD2; HEL-S-67p; maillard deglycase; oncogene DJ1; Parkinson disease (autosomal recessive, early onset) 7; Parkinson disease protein 7; parkinson protein 7; Parkinsonism-associated deglycase; protein deglycase DJ-1; protein DJ-1; protein/nucleic acid deglycase DJ-1

DJ-1 appears to have a function in many biological processes. DJ-1 was first reported as an oncogene and then identified as a gene linked to Parkinson disease, a common neurodegenerative order. DJ-1 has also been observed to play a role in the fertilization process and to act as a sensor for oxidative stress.

The product of this gene belongs to the peptidase C56 family of proteins. It acts as a positive regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress and cell death. Defects in this gene are the cause of autosomal recessive early-onset Parkinson disease 7. Two transcript variants encoding the same protein have been identified for this gene.

11315

Parkinsonism associated deglycase

Parkinsonism associated deglycase

PARK7

HGNC:16369

9606.0

570

Protein deglycase DJ-1

NM_007262

NM_007262, NM_001123377, BC008188,

Apoptosis,Autophagy,Cancer,Immunology,Mitochondrion,mRNA Binding,Neurobiology,Neurodegeneration,Neurodevelopment,Parkinson's Disease,RNA Binding,Signal Transduction,Tumor Suppressors/Oncoproteins

cancer,cell_biology,developmental_biology,genetics,immunology,neurobiology,signal_transduction,transcription_translation

human

DJ-1 appears to have a function in many biological processes. DJ-1 was first reported as an oncogene and then identified as a gene linked to Parkinson disease, a common neurodegenerative order. DJ-1 has also been observed to play a role in the fertilization process and to act as a sensor for oxidative stress.

Hs.419640

Q99497