human PARD3 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human PARD3.
shADV-218217
Ad-h-PARD3-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human PARD3 (par-3 family cell polarity regulator). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
ASIP; atypical PKC isotype-specific interacting protein; Atypical PKC isotype-specific-interacting protein; Ba; Zbazooka; CTCL tumor antigen se2-5; PAR3; PAR-3; par-3 family cell polarity regulator alpha; par-3 partitioning defective 3 homolog; PAR3alpha; PAR3-alpha; PARD-3; PARD3A; partitioning defective 3 homolog; PPP1R118; protein phosphatase 1, regulatory subunit 118; SE2-5L16; SE2-5LT1; SE2-5T2
Description (eCommerce)
Partitioning defective 3 homolog (Par3) is an adapter protein involved in asymmetrical cell division and cell polarization processes. It seems to play a central role in the formation of epithelial tight junctions and targets the phosphatase PTEN to cell junctions (By similarity). Par3 association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. Par3 is required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q8TEW0].
Description (Vector)
PARD3 encodes a member of the PARD protein family. PARD family members interact with other PARD family members and other proteins; they affect asymmetrical cell division and direct polarized cell growth. Multiple alternatively spliced transcript variants have been described for this gene.
Gene ID
56288
Gene Name (eCommerce)
par-3 family cell polarity regulator
Gene Name (Vector)
par-3 family cell polarity regulator
Gene Symbol
PARD3
HGNC ID
HGNC:16051
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
4023
ORF Size (bp)
4023 bp
Protein Name (eCommerce)
Partitioning defective 3 homolog
RefSeq ID
NM_019619
RefSeq Synonyms
NM_019619, NM_001184794, NM_001184793, NM_001184792, NM_001184791, NM_001184790, NM_001184789, NM_001184788, NM_001184787, NM_001184786, NM_001184785, BC071566,
Research Areas
Axonogenesis,Cell Cycle,Cell Division,Cytoskeleton,EGFR Signaling,Hippo Signaling,Immunology,Kinase/Phosphatase,Neurobiology,Signal Transduction,T-cell Receptor Signaling,TGF-beta Signaling
Research Areas (Faceted)
cell_biology,cell_cycle,developmental_biology,genetics,immunology,neurobiology,signal_transduction
Species
human
Target Sentence
Partitioning defective 3 homolog (Par3) is an adapter protein involved in asymmetrical cell division and cell polarization processes. It seems to play a central role in the formation of epithelial tight junctions and targets the phosphatase PTEN to cell junctions (By similarity). Par3 association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. Par3 is required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q8TEW0].
UniGene ID
Hs.131489
UniProt ID (eCommerce)
Q8TEW0
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.