human PAPOLG shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human PAPOLG.
shADV-218195
Ad-h-PAPOLG-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human PAPOLG (poly(A) polymerase gamma). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
neo-PAP; neo-poly(A) polymerase; nuclear poly(A) polymerase gamma; PAP-gamma; poly(A) polymerase gamma; polynucleotide adenylyltransferase gamma; signal recognition particle RNA-adenylating enzyme; SRP RNA 3' adenylating enzyme/pap2; SRP RNA 3'-adenylating enzyme; SRP RNA-adenylating enzyme
Description (eCommerce)
Poly(A) polymerase gamma (PAP-gamma) is a member of the poly(A) polymerase family which catalyzes template-independent extension of the 3' end of a DNA/RNA strand. This enzyme shares 60% identity to the well characterized poly(A) polymerase II (PAPII) at the amino acid level. These two enzymes have similar organization of structural and functional domains. PAP-gamma is exclusively localized in the nucleus and exhibits nonspecific as well as CPSF (cleavage and polyadenylation specificity factor)/AAUAAA-dependent polyadenylation activity [taken from NCBI Entrez Gene (GeneID: 64895)].
Description (Vector)
PAPOLG encodes a member of the poly(A) polymerase family which catalyzes template-independent extension of the 3' end of a DNA/RNA strand. This enzyme shares 60% identity to the well characterized poly(A) polymerase II (PAPII) at the amino acid level. These two enzymes have similar organization of structural and functional domains. This enzyme is exclusively localized in the nucleus and exhibits both nonspecific and CPSF (cleavage and polyadenylation specificity factor)/AAUAAA-dependent polyadenylation activity. PAPOLG is located on chromosome 2 in contrast to the PAPII gene, which is located on chromosome 14.
Gene ID
64895
Gene Name (eCommerce)
poly(A) polymerase gamma
Gene Name (Vector)
poly(A) polymerase gamma
Gene Symbol
PAPOLG
HGNC ID
HGNC:14982
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2211
ORF Size (bp)
2211 bp
Protein Name (eCommerce)
Poly(A) polymerase gamma
RefSeq ID
NM_022894
RefSeq Synonyms
NM_022894, BC113747, BC111701,
Research Areas
mRNA Processing,RNA Binding,RNA Processing,Transcription Factor/Regulator
Research Areas (Faceted)
cell_biology,genetics,transcription_translation
Species
human
Target Sentence
Poly(A) polymerase gamma (PAP-gamma) is a member of the poly(A) polymerase family which catalyzes template-independent extension of the 3' end of a DNA/RNA strand. This enzyme shares 60% identity to the well characterized poly(A) polymerase II (PAPII) at the amino acid level. These two enzymes have similar organization of structural and functional domains. PAP-gamma is exclusively localized in the nucleus and exhibits nonspecific as well as CPSF (cleavage and polyadenylation specificity factor)/AAUAAA-dependent polyadenylation activity [taken from NCBI Entrez Gene (GeneID: 64895)].
UniGene ID
Hs.387471
UniProt ID (eCommerce)
Q9BWT3
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.