human ORC3L shRNA silencing Adenovirus

Name 
Ad-h-ORC3L-shRNA
Cat No 
shADV-217926
Availability
7-8 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human ORC3.

shADV-217926
Ad-h-ORC3L-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human ORC3 (origin recognition complex subunit 3). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Validated
No
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
homolog of latheo, Drosophila; LAT; LATHEO; ORC3L; origin recognition complex subunit 3; origin recognition complex subunit Latheo; origin recognition complex, subunit 3 honolog
Description (eCommerce)
The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. ORC3 is also known as ORC3L and is a subunit of the human ORC complex. ORC3L forms a core complex with ORC2L, -4L, and -5L [taken from NCBI Entrez Gene (GeneID: 23595)].
Description (Vector)
The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Studies of a similar gene in Drosophila suggested a possible role of this protein in neuronal proliferation and olfactory memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene.
Gene ID
23595
Gene Name (eCommerce)
origin recognition complex subunit 3
Gene Name (Vector)
origin recognition complex subunit 3
Gene Symbol
ORC3
HGNC ID
HGNC:8489
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2136
ORF Size (bp)
2136 bp
Protein Name (eCommerce)
Origin recognition complex subunit 3
RefSeq ID
NM_012381
RefSeq Synonyms
NM_181837, NM_012381, NM_001197259, BC035494,
Research Areas
Cell Cycle,DNA Replication,Replication
Research Areas (Faceted)
cell_biology,cell_cycle,genetics,transcription_translation
Species
human
Target Sentence
The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. ORC3 is also known as ORC3L and is a subunit of the human ORC complex. ORC3L forms a core complex with ORC2L, -4L, and -5L [taken from NCBI Entrez Gene (GeneID: 23595)].
UniGene ID
Hs.410228
UniProt ID (eCommerce)
Q9UBD5

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.