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human OGDH shRNA silencing Adenovirus

Name 
Ad-h-OGDH-shRNA
Cat No 
shADV-217373
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human OGDH.

shADV-217373
Ad-h-OGDH-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human OGDH (oxoglutarate dehydrogenase). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
AKGDH; E1k; OGDC
Description (Vector)
OGDH encodes one subunit of the 2-oxoglutarate dehydrogenase complex. This complex catalyzes the overall conversion of 2-oxoglutarate (alpha-ketoglutarate) to succinyl-CoA and CO(2) during the Krebs cycle. The protein is located in the mitochondrial matrix and uses thiamine pyrophosphate as a cofactor. A congenital deficiency in 2-oxoglutarate dehydrogenase activity is believed to lead to hypotonia, metabolic acidosis, and hyperlactatemia. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Gene ID
4967
Gene Name (Vector)
oxoglutarate dehydrogenase
Gene Symbol
OGDH
HGNC ID
HGNC:8124
ORF Size (aa)
3072
ORF Size (bp)
3072 bp
RefSeq ID
NM_002541
RefSeq Synonyms
NM_002541, NM_001165036, NM_001003941, BC014617, BC004964,
Species
human
UniGene ID
Hs.488181

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.