human NTAN1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human NTAN1.
shADV-217151
Ad-h-NTAN1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human NTAN1 (N-terminal asparagine amidase). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
PNAA; PNAD
Description (Vector)
NTAN1 functions in a step-wise process of protein degradation through the N-end rule pathway. This protein acts as a tertiary destabilizing enzyme that deamidates N-terminal L-Asn residues on proteins to produce N-terminal L-Asp. L-Asp substrates are subsequently conjugated to L-Arg, which is recognized by specific E3 ubiquitin ligases and targeted to the proteasome. Pseudogenes of this gene are located on the long arms of chromosomes 8, 10 and 12. Alternative splicing results in multiple transcript variants that encode different protein isoforms.
Gene ID
123803
Gene Name (Vector)
N-terminal asparagine amidase
Gene Symbol
NTAN1
HGNC ID
HGNC:29909
ORF Size (aa)
933
ORF Size (bp)
933 bp
RefSeq ID
NM_173474
RefSeq Synonyms
NM_173474, NM_001270767, NM_001270766, BC017336,
Species
human
UniGene ID
Hs.592045
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.