human NSMCE2 shRNA silencing Adenovirus

Name 
Ad-h-NSMCE2-shRNA
Cat No 
shADV-217116
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human NSMCE2.

shADV-217116
Ad-h-NSMCE2-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human NSMCE2 (NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
C8orf36; E3 SUMO-protein ligase NSE2; E3 SUMO-protein transferase NSE2; hMMS21; methyl methanesulfonate sensitivity gene 21; MMS21; MMS21 homolog; Non-SMC element 2 homolog; non-SMC element 2, MMS21 homolog; non-structural maintenance of chromosomes element 2 homolog; NSE2; NSMCE2/PVT1 fusion; PVT1/NSMCE2 fusion; zinc finger, MIZ-type containing 7; ZMIZ7
Description (eCommerce)
The human MMS21 (Methyl Methanesulfonate-Sensitivity protein 21) homolog is also known as E3 SUMO-protein ligase NSE2. MMS21 is an E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in DNA double-strand break repair by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q96MF7].
Gene ID
286053
Gene Name (eCommerce)
NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase
Gene Name (Vector)
NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase
Gene Symbol
NSMCE2
HGNC ID
HGNC:26513
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
744
ORF Size (bp)
744 bp
Protein Name (eCommerce)
E3 SUMO-protein ligase NSE2
RefSeq ID
NM_173685
RefSeq Synonyms
NM_173685, BC032797,
Research Areas
Aging,Cell Cycle,Cell Division,DNA Damage/Repair,Telomeric Maintenance,Zinc-finger
Research Areas (Faceted)
cell_biology,cell_cycle,genetics,transcription_translation
Species
human
Target Sentence
The human MMS21 (Methyl Methanesulfonate-Sensitivity protein 21) homolog is also known as E3 SUMO-protein ligase NSE2. MMS21 is an E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in DNA double-strand break repair by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q96MF7].
UniGene ID
Hs.388297
UniProt ID (eCommerce)
Q96MF7

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.